circRNA basic information
circBase ID: hsa_circ_0026782
Name: hsa_circ_ITGA7
Synonym: -
Host Gene: hsa-miR-766
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (HCT116, DLD1), normal colonic cell line (FHC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SMAD4
Associated microRNA: hsa-miR-766
Biological function: As shown by cell counting kit-8 assay, flow cytometry, colony formation assay, and xenograft experiment, ectopic overexpression of circ_ITGA7 remarkably restrained CRC tumor growth and enhanced radiosensitivity in vitro and in vivo.
Molecular mechanism: circ_ITGA7/hsa-miR-766/SMAD4 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

In all, circ_ITGA7 suppressed CRC growth and enhanced radiosensitivity by up-regulating SMAD4 through sequestering miR-766, providing an insight for the further development of CRC treatment.
Other information
Title:

circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma.

Journal: Open Med (Wars)
Published: 2023/1/26
PubMed ID: 36694626