circRNA basic information
circBase ID: -
Name: hsa_circ_AR
Synonym: circAR-E2E4
Host Gene: hsa-miR-665, hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human VCap, SK-BR-3, ZR-75-1 cells, human MDA-MB-468, MCF-7 cells , human MDA-MB-231 cells, human MDA-MB-361 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3
Associated microRNA: hsa-miR-665, hsa-miR-671-5p
Biological function: CCK-8 assay showed circAR-E2E4 regulated TNBC cell proliferation.
Molecular mechanism: circAR/hsa-miR-665/STAT3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Collectively, the regulatory network circAR-E2E4-miR-665-STAT3 axis we constructed was associated with TNBC progression, providing a promising diagnostic, prognostic, and therapeutic target in future treatment for TNBC.
Other information
Title:

circAR-E2E4-miR-665-STAT3 axis is a potential regulatory network in triple-negative breast cancer.

Journal: Heliyon
Published: 2023/1/25
PubMed ID: 36691537