circRNA basic information
circBase ID: hsa_circ_0001727
Name: hsa_circ_ZKSCAN1
Synonym: circZKSCAN1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (HCC-LM3, SNU-398, Hep3B, Huh-7, SNU-387), human embryonic kidney cells (293_T), human normal liver cell line (THL-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: FBXW7
Associated microRNA: -
Biological function: -
Molecular mechanism: circZKSCAN1/FBXW7, PI3K/AKT/mTOR pathway
Survival: -
Supported No.:
 3
Description:

These results reveal that a novel circZKSCAN1-encoded peptide acts as a tumor suppressor on PI3K/AKT/mTOR pathway, and sensitizes HCC cells to sorafenib via ubiquitination of mTOR. These findings demonstrated that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment.
Other information
Title:

A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.

Journal: Mol Cancer
Published: 2023/1/24
PubMed ID: 36691031