circRNA basic information
circBase ID: hsa_circ_0029589
Name: hsa_circ_CHFR
Synonym: circ_0029589
Host Gene: hsa-miR-1197
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: RAB22A
Associated microRNA: hsa-miR-1197
Biological function: circ_0029589 silencing ameliorated ox-LDL-triggered HUVEC damage via promoting cell proliferation, tube formation ability, invasion, and repressing cell apoptosis, inflammation, and oxidative stress.
Molecular mechanism: circ_0029589/hsa-miR-1197/RAB22A axis, miRNA sponge
Survival: -
Supported No.:
 6
Description:

Circ_0090231 might protect against ox-LDL-mediated HUVEC injury via the miR-1197/RAB22A axis, which provides a therapeutic strategy for endothelial cell damage of AS.
Other information
Title:

Circular RNA circ_0029589 promotes ox-LDL-induced endothelial cell injury through regulating RAB22A by serving as a sponge of miR-1197.

Journal: Clin Hemorheol Microcirc
Published: 2023/1/24
PubMed ID: 36683504