circRNA basic information
circBase ID: hsa_circ_0000206
Name: hsa_circ_WDR37
Synonym: circWDR37
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HEK293T cells, HONE1, HK1 NPC
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: CircWDR37 deficiency limits cisplatin or gemcitabine-induced senescent NPC cells from proliferation, migration, and invasion.
Molecular mechanism: circWDR37/PKR
Survival: poor
Supported No.:
 1
Description:

This study uncovers a new mechanism of circWDR37 activated PKR in senescence-driven metastasis and provides appealing therapeutic targets in NPC.
Other information
Title:

Chemotherapy-Induced Senescence Reprogramming Promotes Nasopharyngeal Carcinoma Metastasis by circRNA-Mediated PKR Activation.

Journal: Adv Sci (Weinh)
Published: 2023/1/24
PubMed ID: 36683218