circRNA basic information
circBase ID: hsa_circ_0000847
Name: hsa_circ_SMAD2
Synonym: circSMAD2
Host Gene: hsa-miR-1277-5p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal endometrial epithelial cells, EC cells (AN3CA, Ishikawa, KLE, HEC1-B, HEC1-A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MFGE8
Associated microRNA: hsa-miR-1277-5p
Biological function: silencing of circSMAD2 apparently inhibited the proliferation, migration, invasion and angiogenesis of EC cell lines in vitro.
Molecular mechanism: circSMAD2/hsa-miR-1277-5p/MFGE8 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircSMAD2 functions as an oncogene in promoting the progression of EC through miR-1277-5p/MFGE8 axis.
Other information
Title:

CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis.

Journal: J Gynecol Oncol
Published: 2023/1/21
PubMed ID: 36659830