circRNA basic information
circBase ID: hsa_circ_0065898
Name: hsa_circ_VPRBP
Synonym: circVPRBP
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: cervical cancer cell lines (SiHa, HeLa, MS751, C33A, HeLa229, HT-3), a normal cervical cell (H8)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: RACK1
Associated microRNA: -
Biological function: In vitro and in vivo assays showed that circVPRBP overexpression notably inhibited lymphangiogenesis and LN metastasis, whereas RfxCas13d mediated silencing of circVPRBP promoted lymphangiogenesis and the ability of the cervical cancer cells to metastasize to the LNs.
Molecular mechanism: circVPRBP/RACK1 axis
Survival: poor
Supported No.:
 4
Description:

Taken together, the results demonstrate that circVPRBP is a potential prognostic biomarker and a novel therapeutic target for LN metastasis in CCa patients.
Other information
Title:

CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability.

Journal: Oncogene
Published: 2023/1/20
PubMed ID: 36658304