circRNA basic information
circBase ID: hsa_circ_0000078
Name: hsa_circ_USP1
Synonym: circ_0000078
Host Gene: hsa-miR-205-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CC cell lines (HeLa, SiHa, CaSki, C33A), non-cancer cell line (End1/E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: EREG
Associated microRNA: hsa-miR-205-5p
Biological function: Ectopic expression of circ _0000078 not only restrained cancer cell growth, survival, migration, and invasiveness, but also decelerated tumor formation and development in a mouse model.
Molecular mechanism: circ_0000078/hsa-miR-205-5p/EREG axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0000078 inhibits the growth of cancer by interfering with the miR-205-5p/EREG network, acting as a tumor suppressor in CC. These results provide a better understanding of the pathogenesis of this disease.
Other information
Title:

Hsa_circ_0000078 Regulates miR-205-5p/EREG Pathway to Inhibit Cervical Cancer Progression.

Journal: Mol Biotechnol
Published: 2023/1/17
PubMed ID: 36645579