circRNA basic information
circBase ID: hsa_circ_0001811
Name: hsa_circ_STAU2
Synonym: circSTAU2
Host Gene: hsa-miR-589
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cell lines (MKN45, AGS, SGC7901, BGC823, MGC803), gastric mucosal epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: CAPZA1
Associated microRNA: hsa-miR-589
Biological function: CircSTAU2 overexpression inhibited GC cell proliferation, invasion and migration both in vitro and in vivo, while circSTAU2 knockdown had the inverse effect.
Molecular mechanism: circSTAU2/hsa-miR-589/CAPZA1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Exosome-delivered circSTAU2 may act as a tumor suppressor that restrains GC progression via miR-589/CAPZA1 axis, which demonstrates a potential therapeutic target for GC.
Other information
Title:

Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.

Journal: Int J Nanomedicine
Published: 2023/1/17
PubMed ID: 36643863