circRNA basic information
circBase ID: hsa_circ_0001185
Name: hsa_circ_IFNGR2
Synonym: circIFNGR2
Host Gene: hsa-miR-30b
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human colorectal cell lines (FHC, LOVO, DLD1, SW480, HCT116, HCT8, HT29, SW620, CACO2, LS174T, RKO)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KRAS
Associated microRNA: hsa-miR-30b
Biological function: -
Molecular mechanism: circ_IFNGR2/hsa-miR-30b/KRAS axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

We predicted that circIFNGR2 could sponged miR-30b via bioinformatic method and subsequently confirmed that circIFNGR2 promoted the proliferation and migration of CRC cells by targeting miR-30b/KRAS. In addition, we demonstrated that circIFNGR2 might act as a potential chemotherapy resistance marker in CRC.
Other information
Title:

CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b.

Journal: Cell Death Dis
Published: 2023/1/14
PubMed ID: 36639711