circRNA basic information
circBase ID: -
Name: hsa_circ_N4BP2L2
Synonym: circ-N4BP2L2
Host Gene: hsa-miR-135a-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (H1650, PG49, H1299, A549), normal human epithelial cell line (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ARL5B
Associated microRNA: hsa-miR-135a-5p
Biological function: knockdown of circ-N4BP2L2 repressed cell proliferation, invasion as well as mitochondrial function, and promoted cell apoptosis; while overexpression of circ-N4BP2L2 resulted in the opposite results.
Molecular mechanism: circ-N4BP2L2/hsa-miR-135a-5p/ARL5B axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, circ-N4BP2L2 enhanced NSCLC progression via the miR-135a-5p/ARL5B axis, which may provide a novel therapeutic target of NSCLC.
Other information
Title:

Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis.

Journal: Environ Toxicol
Published: 2023/1/14
PubMed ID: 36637163