circRNA basic information
circBase ID: hsa_circ_0069740
Name: hsa_circ_FIP1L1
Synonym: circFIP1L1
Host Gene: hsa-miR-125a-5p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human nasopharyngeal epithelial cell line (NP69), NPC cell lines (5-8F, CNE1, HNE1), human umbilical vein endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFA
Associated microRNA: hsa-miR-125a-5p
Biological function: GS promoted the secretion of exosomal circFIP1L1 from HNE1 cells to affect HUVECs proliferation and angiogenesis.
Molecular mechanism: circFIP1L1/hsa-miR-125a-5p/VEGFA axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

GS promoted exosomal circFIP1L1 in NPC cells to mediate miR-125a-5p/VEGFA axis affecting tumor angiogenesis.
Other information
Title:

Guggulsterone Promotes Nasopharyngeal Carcinoma Cells Exosomal Circfip1L1 to Mediate miR-125a-5p/VEGFA Affecting Tumor Angiogenesis.

Journal: Curr Mol Pharmacol
Published: 2023/1/14
PubMed ID: 36635928