circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF236
Synonym: circZNF236
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cell lines (namely SCC-9, HSC-3, SCC-15, CAL-27, SCC-25), human oral keratinocytes (HOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MBTD1
Associated microRNA: hsa-miR-145-5p
Biological function: CircZNF236 silencing decreased the malignant properties of OSCC cells and suppressed OSCC tumor formation in the mouse model.
Molecular mechanism: circZNF236/hsa-miR-145-5p/MBTD1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

CircZNF236 modulates OSCC via the miR-145-5p/MBTD1 axis. These results support the potential of circZNF236 as a treatment target for OSCC.
Other information
Title:

CircZNF236 facilitates malignant progression in oral squamous cell carcinoma by sequestering miR-145-5p.

Journal: Clin Transl Oncol
Published: 2023/1/13
PubMed ID: 36635458