circRNA basic information
circBase ID: hsa_circ_0007334
Name: hsa_circ_MBOAT2
Synonym: circMBOAT2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4928
DO name: intrahepatic cholangiocarcinoma
Disease details: intrahepatic cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human cholangiocarcinoma cell lines (RBE, HCCC-9810, HuCCT1, CCLP1, QBC-939), a human normal bile duct epithelial cell line (H69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PTBP1, FASN
Associated microRNA: -
Biological function: circMBOAT2 knockdown inhibits the growth and metastasis of ICC cells.
Molecular mechanism: circMBOAT2/PTBP1/FASN axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our results identified that circMBOAT2 was upregulated in ICC and promoted progression by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export, which altered lipid metabolic profile and regulated redox homeostasis in ICC, suggesting that circMBOAT2 may serve as an available therapeutic target for ICC with active lipid metabolism.
Other information
Title:

CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.

Journal: Cell Death Dis
Published: 2023/1/13
PubMed ID: 36635270