circRNA basic information
circBase ID: hsa_circ_0069280
Name: hsa_circ_NCAPG
Synonym: circNCAPG
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cell lines (U87, U251, LN229)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: U2AF65, RREB1
Associated microRNA: -
Biological function: -
Molecular mechanism: U2AF65/circNCAPG/RREB1 axis, TGF-beta1 signaling pathway
Survival: poor
Supported No.:
 1
Description:

Our findings support the existence of a novel feedback loop U2AF65/circNCAPG/RREB1 that promotes malignant progression in GSCs and could be a novel therapeutic target for glioma patients.
Other information
Title:

The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-beta pathway.

Journal: Cell Death Dis
Published: 2023/1/13
PubMed ID: 36635261