circRNA basic information
circBase ID: hsa_circ_0060937
Name: hsa_circ_CYP24A1
Synonym: circ_0060937
Host Gene: hsa-miR-1304-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: lung cancer cells (A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LAD1
Associated microRNA: hsa-miR-1304-5p
Biological function: circ_0060937 downregulation repressed A549 and H1299 cell proliferative, migratory, invasive, and sphere formation abilities, and circ_0060937 absence also decelerated tumorigenesis in animal models.
Molecular mechanism: circ_0060937/hsa-miR-1304-5p/LAD1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0060937 downregulation decreased the expression of LAD1 by releasing miR-1304-5p to effectively repress lung cancer cell growth and in vivo tumorigenesis.
Other information
Title:

Circ_0060937 Contributes to the Development of Lung Cancer via Positively Regulating LAD1 Expression by Binding to miR-1304-5p.

Journal: Biochem Genet
Published: 2023/1/13
PubMed ID: 36633773