circRNA basic information
circBase ID: hsa_circ_0000004
Name: hsa_circ_ATAD3B
Synonym: circ_0000004
Host Gene: hsa-miR-1303
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteosarcoma cell lines (143B, MG-63)
circRNA-disease information
Detected method:
Q
S
M
Detected method confidence High
Expression pattern:
UP
Associated gene: APLN, PLOD2
Associated microRNA: hsa-miR-1303
Biological function: -
Molecular mechanism: hsa_circ_0000004/hsa-miR-1303 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

APLN increased PLOD2 expression in human osteosarcoma cell lines and cell migration via the mammalian Sterile 20-like kinase 1 (MST1), monopolar spindle-one-binder protein (MOB)1, and YAP cascades, and through hsa_circ_0000004 functioning as a sponge of miR-1303.
Other information
Title:

Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis.

Journal: Int J Biol Sci
Published: 2023/1/13
PubMed ID: 36632453