circRNA basic information
circBase ID: hsa_circ_0000979
Name: hsa_circ_TCONS_00003590
Synonym: Circ-0000979
Host Gene: hsa-miR-136
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal gastric epithelial cells (GSE-1), GC cell lines (AGS, HGC27, MKN-45, MKN7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SP1
Associated microRNA: hsa-miR-136
Biological function: silencing circ-0000979 leads to a significant reduction in GC cell proliferation and migration. In vivo assays showed that circ-0000979 knockdown markedly reduced GC tumor growth.
Molecular mechanism: circ-0000979/hsa-miR-136/SP1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, our results demonstrated that circ-0000979, as a carcinogenic circRNA, promotes the progression of GC by regulating the miR-136/SP1 pathway. Circ-0000979 is a potential RNA-based therapeutic target for GC treatment.
Other information
Title:

Circ-0000979 promotes the development of gastric carcinoma by sponging miR-136 and modulating SP1 mRNA expression level.

Journal: Histol Histopathol
Published: 2023/1/12
PubMed ID: 36629013