circRNA basic information
circBase ID: hsa_circ_0000644
Name: hsa_circ_KIAA1199
Synonym: circ_0000644
Host Gene: hsa-miR-143-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ureteral epithelial cells SV-HUC-1, BCa cells HT1376, 293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RUNX3
Associated microRNA: hsa-miR-143-3p
Biological function: -
Molecular mechanism: circ_644/hsa-miR-143-3p/RUNX3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

This study demonstrates that transcriptional activation of circ_644 upon RUNX3 downregulation drives the malignant development of BCa through the miR-143-3p/MSI2 axis. RUNX3 restoration or specific inhibition of circ_644 or MSI2 may help block BCa progression.
Other information
Title:

Increased transcription of hsa_circ_0000644 upon RUNX family transcription factor 3 downregulation participates in the malignant development of bladder cancer.

Journal: Cell Signal
Published: 2023/1/11
PubMed ID: 36627006