circRNA basic information
circBase ID: -
Name: hsa_circ_MAN1A2
Synonym: CircMAN1A2
Host Gene: hsa-miR-135a-3p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human nasopharyngeal cell line (NP69), human NPC cell lines (HK-1, C666-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: UBR5
Associated microRNA: hsa-miR-135a-3p
Biological function: results of EdU and colony formation assays suggested that the proliferative and clonogenic ability of HK-1 and C666-1 cells was attenuated in the presence of circMAN1A2 knockdown
Molecular mechanism: circMAN1A2/hsa-miR-135a-3p/UBR5 axis, miRNA sponge
Survival: poor
Supported No.:
 2
Description:

Together, our study uncovered the tumor-initiating and pro-metastatic role of circMAN1A2-miR-135a-3p-UBR5-ATMIN axis in NPC regulation that may be a potential therapeutic target for human NPC.
Other information
Title:

CircMAN1A2 contributes to nasopharyngeal carcinoma progression via enhancing the ubiquitination of ATMIN through miR-135a-3p/UBR5 axis.

Journal: Hum Cell
Published: 2023/1/11
PubMed ID: 36626032