circRNA basic information
circBase ID: -
Name: hsa_circ_FLNA
Synonym: circFLNA
Host Gene: hsa-miR-766-3p
 
 
 
Disease basic information
DO ID:
 5295
DO name: intestinal disease
Disease details: intestinal injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: bormal HIEC-6 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FAS
Associated microRNA: hsa-miR-766-3p
Biological function: circFLNA aggravated apoptosis and inflammation through the Fas-mediated apoptosis pathway in both LPS-treated HIEC-6 cells and a mouse cecal ligation and puncture model.
Molecular mechanism: circFLNA/hsa-miR-766-3p/Fas axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

The circFLNA/miR-766-3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis.
Other information
Title:

circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p.

Journal: Inflamm Res
Published: 2023/1/11
PubMed ID: 36625877