circRNA basic information
circBase ID: hsa_circ_0059773
Name: hsa_circ_POFUT1
Synonym: circPOFUT1
Host Gene: hsa-miR-488-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human epithelial GES-1 cells, GC cells BGC-823, AGS, HGC-27, MGC-803, SGC-7901, MKN-45
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PLAG1, ATG12
Associated microRNA: hsa-miR-488-3p
Biological function: overexpression of circPOFUT1 enhanced cell proliferation, migration, invasion and autophagy-associated chemoresistance in GC. Overexpression of circPOFUT1 enhanced autophagy-associated chemoresistance of GC cells in vivo
Molecular mechanism: circPOFUT1/hsa-miR-488-3p/PLAG1/ATG12 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Our findings show the potential of circPOFUT1 as biomarkers and targeting circPOFUT1 as a therapeutic strategy for GC.
Other information
Title:

Circular RNA circPOFUT1 enhances malignant phenotypes and autophagy-associated chemoresistance via sequestrating miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer.

Journal: Cell Death Dis
Published: 2023/1/10
PubMed ID: 36624091