circRNA basic information
circBase ID: hsa_circ_0001481
Name: hsa_circ_EMB
Synonym: circEMB
Host Gene: hsa-miR-3184-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal osteoblast cell line (hFOB1.19), human OSA cell lines (143B, U2OS, MNNG, MG63, Saos-2)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR
Associated microRNA: hsa-miR-3184-5p
Biological function: In vitro experiments revealed that circEMB knockdown decreased cell proliferation, inhibited tumour invasion and metastasis; increased apoptosis and resulted in G1/S phase arrest. In vivo experiments revealed that circEMB knockdown inhibited tumour growth and metastasis in xenograft-bearing mice.
Molecular mechanism: circEMB/hsa-miR-3184-5p/EGFR axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircEMB plays a critical role in promoting cancer via the miR-3184-5p/EGFR pathway, indicating that circEMB may serve as a therapeutic target for OSA.
Other information
Title:

Circular RNA circEMB promotes osteosarcoma progression and metastasis by sponging miR-3184-5p and regulating EGFR expression.

Journal: Biomark Res
Published: 2023/1/8
PubMed ID: 36611218