circRNA basic information
circBase ID: hsa_circ_0021727
Name: hsa_circ_CD44
Synonym: circ_0021727
Host Gene: hsa-miR-23b-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (TE-1, KYSE510)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TAB1
Associated microRNA: hsa-miR-23b-5p
Biological function: hsa_circ_0021727 promoted the proliferation, invasion, and migration of ESCC cells.
Molecular mechanism: hsa_circ_0021727/hsa-miR-23b-5p/TAB1 NFkappaB pathway, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

In short, hsa_circ_0021727 promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NF¦ĘB pathway. These findings might provide potential targets to treat ESCC.
Other information
Title:

Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFkappaB pathway.

Journal: Cell Death Dis
Published: 2023/1/8
PubMed ID: 36609391