circRNA basic information
circBase ID: hsa_circ_0002980
Name: hsa_circ_AGK
Synonym: circAGK
Host Gene: hsa-miR-3180-5p
 
 
 
Disease basic information
DO ID:
 0050801
DO name: androgenic alopecia
Disease details: androgenetic alopecia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: BAX
Associated microRNA: hsa-miR-3180-5p
Biological function: CircAGK promoted DPC apoptosis in the presence of high dihydrotestosterone
Molecular mechanism: circAGK/hsa-miR-3180-5p/BAX axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

By regulating the miR-3180-5p/BAX axis, circAGK promotes DPC apoptosis in a high DHT environment in vitro and inhibits hair growth in AGA mice in vivo, indicating that circAGK is a potential target for the clinical treatment of AGA.
Other information
Title:

CircAGK regulates high dihydrotestosterone-induced apoptosis in DPCs through the miR-3180-5p/BAX axis.

Journal: FASEB J
Published: 2023/1/7
PubMed ID: 36607259