circRNA basic information
circBase ID: -
Name: hsa_circ_SETD3
Synonym: circSETD3
Host Gene: hsa-miR-653
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: colorectal cancer cell lines (SW480, LoVo), normal colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF6
Associated microRNA: hsa-miR-653
Biological function: circSETD3 directly sponged miR-653 and negatively regulate miR-653 to affect proliferation, migration, invasion, and apoptosis of CRC cells.
Molecular mechanism: circSETD3/hsa-miR-653/KLF6 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Taken together, these findings indicated that circSETD3/miR-653/KLF6 axis may be an effective therapeutic target for CRC patients.
Other information
Title:

Hypoxia-induced miR-653 enhances colorectal cancer progression by targeting circSETD3/KLF6 axis.

Journal: J Cancer
Published: 2023/1/7
PubMed ID: 36605481