circRNA basic information
circBase ID: hsa_circ_0000390
Name: hsa_circ_FGD4
Synonym: circ_0000390
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CACO-2 (HTB-37), HCT116 (CCL-247), Lovo (CCL-229), SW620 (CCL-227), SW480 (CCL-228), RKO (CRL-2577) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: METTL3, Notch1
Associated microRNA: -
Biological function: results showed circ_0000390 overexpression suppressed the proliferation, cell migration, and invasion of CRC cells
Molecular mechanism: circ_0000390/METTL3/Notch1 axis
Survival: -
Supported No.:
 1
Description:

This study suggested that circ_0000390 might be anti-tumor factor in CRC and METTL3/Notch1 might be a therapeutic targets for CRC.
Other information
Title:

METTL3-mediated Hsa_circ_0000390 downregulation enhances the proliferation, migration, and invasion of colorectal cancer cells by increasing Notch1 expression.

Journal: Hum Cell
Published: 2023/1/5
PubMed ID: 36600025