circRNA basic information
circBase ID: hsa_circ_0000028
Name: hsa_circ_USP48
Synonym: circUSP48
Host Gene: hsa-miR-335
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OS cell lines (MG-63, 143B, U2OS, Saos-2), human osteoblasts (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SNIP1
Associated microRNA: hsa-miR-335
Biological function: Silencing circUSP48 could suppress proliferation, invasion as well as migration of OS cells in vitro, also inhibiting the growth of tumor in vivo.
Molecular mechanism: circUSP48/hsa-miR-335/SNIP1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Overall, these findings suggested that circUSP48 acted as an oncogene in OS, which might become a new target for OS therapy.
Other information
Title:

Silencing circUSP48 suppresses osteosarcoma progression by regulating the miR-335/ smad nuclear interacting protein 1 pathway.

Journal: J Clin Lab Anal
Published: 2023/1/5
PubMed ID: 36597862