circRNA basic information
circBase ID: hsa_circ_0008304
Name: hsa_circ_TFDP2
Synonym: circTFDP2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PARP1, eIF4A3
Associated microRNA: -
Biological function: circTFDP2 promoted PCa cell proliferation and metastasis both in vivo and in vitro
Molecular mechanism: circTFDP2/PARP1, circTFDP2/eIF4A3
Survival: -
Supported No.:
 1
Description:

In general, our study demonstrated that circTFDP2 promoted PCa cell progression through the PARP1/DNA damage axis, which may be a promising therapeutic target for PCa.
Other information
Title:

Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage.

Journal: Clin Transl Med
Published: 2023/1/4
PubMed ID: 36597139