circRNA basic information
circBase ID: hsa_circ_0022383
Name: hsa_circ_FADS2
Synonym: hsa_circRNA_100833
Host Gene: hsa-miR-765, hsa-miR-495-3p, hsa-miR-665, hsa-miR-193b-5p, hsa-miR-124-5p
 
 
 
Disease basic information
DO ID:
 3151
DO name: skin squamous cell carcinoma
Disease details: cutaneous squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-765, hsa-miR-495-3p, hsa-miR-665, hsa-miR-193b-5p, hsa-miR-124-5p
Biological function: -
Molecular mechanism: interfering with cSCC relevant miRNAs through miRNA sequence complementary MREs participating in epigenetic control
Survival: -
Supported No.:
 3
Description:

Regarding the top down-regulated circRNAs, hsa_circ_0022392 and hsa_circ_0022383 are both spliced from Fatty Acid Desaturase 2 (FADS2), which is localized at the cancer genomic hotspot 11q13 locus and codes for an enzyme with ?_6 and ?_8-desaturase activity necessary for normal eicosanoid precursor synthesis previously shown in human breast 19 cancer cells.
Other information
Title:

Circular RNA expression in cutaneous squamous cell carcinoma.

Journal: J Dermatol Sci
Published: 2016/6/15
PubMed ID: 27298156