circRNA basic information
circBase ID: hsa_circ_0006988
Name: hsa_circ_LDLRAD3
Synonym: circ_0006988
Host Gene: hsa-miR-15a-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: cancer cell lines (HCC, HepG2, Huh-7 ), normal human liver cell line (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1
Associated microRNA: hsa-miR-15a-5p
Biological function: -
Molecular mechanism: hsa_circ_0006988/hsa-miR-15a-5p/IGF1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0006988 partly promoted the SOR-R of HCC cells through miR-15a-5p sequestering and upregulation of IGF1 levels.
Other information
Title:

Hsa_circ_0006988 Promotes Sorafenib Resistance of Hepatocellular Carcinoma by Modulating IGF1 Using miR-15a-5p.

Journal: Can J Gastroenterol Hepatol
Published: 2023/1/4
PubMed ID: 36594050