circRNA basic information
circBase ID: hsa_circ_0000520
Name: hsa_circ_RPPH1
Synonym: circ_0000520
Host Gene: hsa-miR-1258
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (NCI-H1299, A549, H460, NCI-H2106, H1975), immortalized bronchial epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT3
Associated microRNA: hsa-miR-1258
Biological function: Highly expressed circ_0000520 is linked to the NSCLC patients advanced TNM stage and lymph node metastasis. circ_0000520 overexpression facilitated NSCLC cell growth, migration, and invasion.
Molecular mechanism: circ_0000520/hsa-miR-1258/AKT3 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

circ_0000520 upregulates AKT3 by competitively binding with miR-1258 to facilitate NSCLC progression.
Other information
Title:

Hsa_circ_0000520 Promotes Non-Small Cell Lung Cancer Progression through the miR-1258/AKT3 Axis.

Journal: J Oncol
Published: 2023/1/4
PubMed ID: 36593867