circRNA basic information
circBase ID: hsa_circ_0006646
Name: hsa_circ_PTK2
Synonym: Circ_0006646
Host Gene: hsa-miR-758-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CC cell lines (SiHa, CaSki, C33A, HeLa), human cervical epithelial cell line (Ect1/E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RRM2
Associated microRNA: hsa-miR-758-3p
Biological function: Circ_0006646 expression was elevated in CC cells, and its knockdown suppressed CC cell growth, migration, and invasion.
Molecular mechanism: circ_0006646/hsa-miR-758-3p/RRM2 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0006646 expedited CC cell growth and metastasis by regulating miR-758-3p/RRM2 axis, and exosomal circ_0006646 might be a potential diagnostic indicator of CC.
Other information
Title:

Circ_0006646 Accelerates the Growth and Metastasis of Cervical Cancer by Elevating RRM2 Through miR-758-3p.

Journal: Biochem Genet
Published: 2022/12/31
PubMed ID: 36583788