circRNA basic information
circBase ID: hsa_circ_0049396
Name: hsa_circ_LDLR
Synonym: circ_0049396
Host Gene: hsa-miR-663b
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cell lines (HSC-2, SJG-1, H157), HEK293T cells, human immortalized oral epithelial cells (HIOEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ENDOU
Associated microRNA: hsa-miR-663b
Biological function: Circ_0049396 overexpression weakened OSCC cell proliferation and migration but enhanced their apoptosis. Circ_0049396 overexpression suppresses tumorigenesis in vivo.
Molecular mechanism: hsa_circ_0049396/hsa-miR-663b/ENDOU axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our study illustrated that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis. Based on our findings, circ_0049396 can be used as a potential therapeutic agent for OSCC.
Other information
Title:

Hsa_circ_0049396 inhibited oral squamous cell carcinoma progression by regulating the miR-663b/ENDOU axis.

Journal: Genomics
Published: 2022/12/30
PubMed ID: 36581129