circRNA basic information
circBase ID: hsa_circ_0000168
Name: hsa_circ_DENND1B
Synonym: -
Host Gene: hsa-miR-122-5p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: renal cancer cell lines (786-O, 769-P), human renal epithelial cells (HK-2)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: TIMP2
Associated microRNA: hsa-miR-122-5p
Biological function: miR-122-5p upregulation reversed the effects of circ_DENND1B on cell proliferation, migration, invasion and apoptosis. circ_DENND1B overexpression inhibited the tumor growth of ccRCC in vivo.
Molecular mechanism: circ_DENND1B/hsa-miR-122-5p/TIMP2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ_DENND1B inhibited ccRCC cell progression by promoting TIMP2 expression by sponging miR-122-5p, suggesting that circ_DENND1B might be an effective therapeutic target for ccRCC.
Other information
Title:

circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis.

Journal: Open Med (Wars)
Published: 2022/12/30
PubMed ID: 36578555