circRNA basic information
circBase ID: -
Name: hsa_circ_PGAM1
Synonym: Circ-PGAM1
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (H1299, A549), human normal lung epithelial cells (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCR5
Associated microRNA: hsa-miR-326
Biological function: circ-PGAM1 overexpression reversed the matrine treatment-induced inhibition on proliferation of NSCLC cells (A549 and H1299) and rescued the matrine treatment-stimulated apoptosis of these cells.
Molecular mechanism: circ-PGAM1/hsa-miR-326/CXCR5 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ-PGAM1 enhances matrine resistance of NSCLC cells through the miR-326/CXCR5 axis. The authors findings provide new insights into NSCLC-targeted therapy.
Other information
Title:

Circ-PGAM1 Enhances Matrine Resistance of Non-Small Cell Lung Cancer via the miR-326/CXCR5 Axis.

Journal: Cancer Biother Radiopharm
Published: 2022/12/29
PubMed ID: 36576783