circRNA basic information
circBase ID: hsa_circ_0020378
Name: hsa_circ_DOCK1
Synonym: circ_0020378
Host Gene: hsa-miR-556-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal osteoblast cells (hFOB1.19), OS cells (SOSP-9607, SW1353, Saos-2, HOS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MAPK1
Associated microRNA: hsa-miR-556-5p
Biological function: Circ_0020378 silence attenuated OS cell proliferation, colony formation ability and migration in vitro, and retarded tumor growth in vivo.
Molecular mechanism: hsa_circ_0020378/hsa-miR-556-5p/MAPK1 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

Circ_0020378 acts as a novel tumor promoter that controls OS growth by miR-556-5p/MAPK1 axis, suggesting circ_0020378/miR-556-5p/MAPK1 might be a novel target for OS intervention.
Other information
Title:

Hsa_circ_0020378 targets miR-556-5p/MAPK1 to regulate osteosarcoma cell proliferation and migration.

Journal: Gene
Published: 2022/12/27
PubMed ID: 36572073