circRNA basic information
circBase ID: hsa_circ_0008922
Name: hsa_circ_MATR3
Synonym: circ_0008922
Host Gene: hsa-let-7e-5p, hsa-miR-506-5p, hsa-let-7b-5p, hsa-let-7c-5p, hsa-let-7a-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: glioma cell lines (A172, U251)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: KPNA4
Associated microRNA: hsa-let-7e-5p, hsa-miR-506-5p, hsa-let-7b-5p, hsa-let-7c-5p, hsa-let-7a-5p
Biological function: The expression of has_circ_0008922 was correlated with WHO tumor grade. After down-regulating the expression of hsa_circ_0008922, malignant biological behavior of glioma cells was inhibited, such as cell proliferation, colony formation, migration, and invasion. At the same time, it also induced apoptosis of glioma cells.
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

We found that the expression of hsa_circ_0008922 in glioma tissues was 3.4 times higher than that in normal tissues. The expression of has_circ_0008922 was correlated with WHO tumor grade. After down-regulating the expression of hsa_circ_0008922, malignant biological behavior of glioma cells was inhibited, such as cell proliferation, colony formation, migration, and invasion.
Other information
Title:

Knockdown of hsa_circ_0008922 inhibits the progression of glioma.

Journal: PeerJ
Published: 2022/12/27
PubMed ID: 36570001