circRNA basic information
circBase ID: hsa_circ_0007841
Name: hsa_circ_SEC61A1
Synonym: circSEC61A1
Host Gene: hsa-miR-513a-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bronchial epithelial cell line (BEAS-2B), NSCLC cell lines (A549, H1299, Calu-3, H520, H1650)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PEX5
Associated microRNA: hsa-miR-513a-5p
Biological function: circSEC61A1 overexpression promoted NSCLC malignant phenotypes, glycolysis, EMT, and Wnt/beta-catenin pathway activation, whereas circSEC61A1 underexpression did the opposite. Knockdown of circSEC61A1 limited tumor growth and metastasis.
Molecular mechanism: circSEC61A1/hsa-miR-513a-5p/PEX5 axis, miRNA sponge
Survival: better
Supported No.:
 2
Description:

Generally, circSEC61A1 is a potential biomarker for NSCLC, and circSEC61A1 serves tumor-promoting action in the progression of NSCLC.
Other information
Title:

Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA-513a-5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non-small cell lung cancer.

Journal: Kaohsiung J Med Sci
Published: 2022/12/27
PubMed ID: 36567627