circRNA basic information
circBase ID: hsa_circ_0075043
Name: hsa_circ_DUSP1
Synonym: CircDUSP1
Host Gene: hsa-miR-761
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: TNBC cell lines (BT-549, SUM-159, MDA-MB-231, MDA-MB-468, HCC38), non-TNBC cell lines (MCF-10A), non-tumorigenic mammary epithelial cell line (MCF10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: DACT2
Associated microRNA: hsa-miR-761
Biological function: Overexpression of circDUSP1 significantly attenuated cell proliferation, migration, invasion, and epithelial-mesenchymal transition, while increased the sensitivity of TNBC cells to paclitaxel.
Molecular mechanism: circDUSP1/hsa-miR-761/DACT2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, our findings revealed a role for the regulation of the miR-761/DACT2 axis by circDUSP1 in the biological process of TNBC. These results provided new insights into the biological mechanism and targeted therapy of TNBC.
Other information
Title:

CircDUSP1 regulates tumor growth, metastasis, and paclitaxel sensitivity in triple-negative breast cancer by targeting miR-761/DACT2 signaling axis.

Journal: Mol Carcinog
Published: 2022/12/24
PubMed ID: 36562476