circRNA basic information
circBase ID: hsa_circ_0001821
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 5409
DO name: lung small cell carcinoma
Disease details: small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MYC amplification cell lines (GLC1DM, GLC1HSR, GLC2, GLC3, NCI-H2171), MYCL amplification cell lines (GLC26, GLC28, H1963, H510A, HCC33, H2141, H1184), MYCN amplification cell lines (GLC8, GLC14), normal bronchial epithelial cell line (BEAS-2B), cervix epithelioid carcinoma cell line (HeLa )
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PVT1, AKT3, MYC
Associated microRNA: -
Biological function: circPVT1 activated a pro-proliferative and anti-apoptotic program when over-expressed in lung cells, and knockdown of chimPVT1 induced a decrease in cell growth and an increase of apoptosis in SCLC in vitro
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

In conclusion, we have uncovered a functional role of circular and chimeric PVT1 transcripts in SCLC; these entities may prove useful as novel biomarkers in MYC-amplified tumors.
Other information
Title:

circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer.

Journal: Genes Chromosomes Cancer
Published: 2022/12/24
PubMed ID: 36562080