circRNA basic information
circBase ID: hsa_circ_0020378
Name: hsa_circ_DOCK1
Synonym: CircDOCK1
Host Gene: hsa-miR-186
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal hFOB 1.19 osteoblasts, OS (HOS, U2OS) cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: DNMT3A
Associated microRNA: hsa-miR-186
Biological function: By knocking down circDOCK1, cellular multiplication, motility, and invasion were suppressed. Furthermore, silencing circDOCK1 suppressed the growth of tumor xenografts.
Molecular mechanism: circDOCK1/hsa-miR-186/DNMT3A axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

CircDOCK1 promotes OS progression by interacting with miR-186/DNMT3ADNMT3A, representing a novel therapeutic approach.
Other information
Title:

CircDOCK1 Regulates miR-186/DNMT3A to Promote Osteosarcoma Progression.

Journal: Biomedicines
Published: 2022/12/24
PubMed ID: 36551768