circRNA basic information
circBase ID: hsa_circ_00090655
Name: hsa_circ_BFAR
Synonym: CircBFAR
Host Gene: hsa-miR-31-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LSCC cell lines (TU177, M4E, AMC_HN_8, TU686), normal nasopharyngeal cell line (NP69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: COL5A1
Associated microRNA: hsa-miR-31-5p
Biological function: The cell viability and proliferation were inhibited by circBFAR knockdown and silencing of circBFAR blocked migration and invasion of LSCC cells. CircBFAR knockdown suppressed cell tube formation, and the protein expression of KI-67, matrix metallopeptidase 2 (MMP2), and vascular endothelial growth factor A (VEGFA) in LSCC cells.
Molecular mechanism: CircBFAR/hsa-miR-31-5p/COL5A1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

CircBFAR, miR-31-5p, and COL5A1 in LSCC progression might provide novel therapeutic targets for LSCC clinical intervention.
Other information
Title:

CircBFAR correlates with poor prognosis and promotes laryngeal squamous cell cancer progression through miR-31-5p/COL5A1 axis.

Journal: Laryngoscope Investig Otolaryngol
Published: 2022/12/23
PubMed ID: 36544920