circRNA basic information
circBase ID: hsa_circ_0005962
Name: hsa_circ_YWHAZ
Synonym: circ_0005962
Host Gene: hsa-miR-3611
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human bronchial epithelial cells (BEAS-2B, CL-0496), LUAD cell lines (A549, CL-0016; HCC827, CL-0094; H1975, CL-0298)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CYP24A1
Associated microRNA: hsa-miR-3611
Biological function: Functional assays testified that circ_0005962 depletion might hinder LUAD cell proliferation and sphere formation capability, but induced cell apoptosis in vitro.
Molecular mechanism: circ_0005962/hsa-miR-3611/CYP24A1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Together, circ_0005962 was overexpressed in LUAD, and its deficiency repressed LUAD progression via targeting the miR-3611/ CYP24A1 axis, providing a novel mechanism for understanding the development of LUAD.
Other information
Title:

Circular RNA Circ_0005962 Contributes to Lung Adenocarcinoma Cell Proliferation and Stem Cell Formation Through Sponging of miR-3611 and Modulating CYP24A1 Expression.

Journal: Biochem Genet
Published: 2022/12/22
PubMed ID: 36542209