circRNA basic information
circBase ID: hsa_circ_0004639
Name: hsa_circ_PVRL3
Synonym: circPVRL3
Host Gene: hsa-miR-194-5p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: PANC-1, BxPC-3, AsPC-1, CFPAC-1, SW1990, HPDE-C7
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SOCS2
Associated microRNA: hsa-miR-194-5p
Biological function: -
Molecular mechanism: circPVRL3/hsa-miR-194-5p/SOCS2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our findings indicated that an increase of miR-194-5p caused by circPVRL3 downregulation stimulates the PI3K/AKT signaling pathway to promote PDAC progression via the circPVRL3/miR-194-5p/SOCS2 axis, which suggests that the circPVRL3/miR-194-5p/SOCS2 axis may be a potential therapeutic target for PDAC patients.
Other information
Title:

Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathway.

Journal: Cancer Cell Int
Published: 2022/12/21
PubMed ID: 36539807