circRNA basic information
circBase ID: hsa_circ_0001079
Name: hsa_circ_STK39
Synonym: CircSTK39
Host Gene: hsa-miR-135a-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BCa cell lines (5637, T24, EJ)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: NR3C2
Associated microRNA: hsa-miR-135a-5p
Biological function: Ectopic expression of circSTK39 decreased cell proliferation, colony formation, and invasion capacities, while circSTK39 knockdown prevented the above phenotypes.
Molecular mechanism: EMT processes, circSTK39/hsa-miR-135a-5p/NR3C2 axis, miRNA sponge
Survival: better
Supported No.:
 1
Description:

In conclusion, our results revealed that circSTK39 inhibited EMT of BCa cells through the miR-135a-5p/NR3C2 axis and may provide promising biomarkers for the diagnosis or prospective therapeutic targets for BCa.
Other information
Title:

CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway.

Journal: Cell Biol Toxicol
Published: 2022/12/21
PubMed ID: 36538242