circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: Circ_0000284
Host Gene: hsa-miR-1179
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SW1990, CAPAN1, HPDE
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RHPN2
Associated microRNA: hsa-miR-1179
Biological function: promote cell proliferation, migration, invasion, and angiogenesis, inhibit apoptosis
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

To sum up, our data confirmed that circ_0000284 facilitated PC malignant progression depending on the regulation of miR-1179/RHPN2 axis, suggesting that circ_0000284 might be a potential target for PC treatment.
Other information
Title:

Circ_0000284 upregulates RHPN2 to facilitate pancreatic cancer proliferation, metastasis, and angiogenesis through sponging miR-1179.

Journal: J Biochem Mol Toxicol
Published: 2022/12/20
PubMed ID: 36536496