circRNA basic information
circBase ID: -
Name: hsa_circ_SHPRH
Synonym: circ-SHPRH
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: glioblastoma cells (U251, U373)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PCNA, SHPRH-146aa
Associated microRNA: -
Biological function: -
Molecular mechanism: SHPRH-146aa protects full-length SHPRH from degradation by the ubiquitin proteasome
Survival: -
Supported No.:
 2
Description:

Our findings provide a novel perspective regarding circRNA function in physiological and pathological processes. Specifically, SHPRH-146aa generated from overlapping genetic codes of circ-SHPRH is a tumor suppressor in human glioblastoma.
Other information
Title:

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.

Journal: Oncogene
Published: 2018/1/19
PubMed ID: 29343848