circRNA basic information
circBase ID: hsa_circ_0002360
Name: hsa_circ_RUNX1
Synonym: circRUNX1
Host Gene: hsa-miR-449b-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal esophageal epithelial cell line HEEC, human ESCC cell lines (KYSE450, EC109, TE1, KYSE70, KYSE150), HEK-293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXP3, IGF2BP2
Associated microRNA: hsa-miR-449b-5p
Biological function: promoted ESCC cell proliferation and metastasis
Molecular mechanism: circRUNX1/hsa-miR-449b-5p/FOXP3 axis
Survival: -
Supported No.:
 1
Description:

IGF2BP2 mediated circRUNX1 functions as an oncogenic factor to facilitate ESCC progression through the miR-449b-5p/FOXP3 axis, implying that circRUNX1 has the potential to be a promising diagnostic marker and therapeutic target for ESCC patients.
Other information
Title:

IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis.

Journal: J Exp Clin Cancer Res
Published: 2022/12/16
PubMed ID: 36522683