circRNA basic information
circBase ID: hsa_circ_0006357
Name: hsa_circ_EZH2
Synonym: circEZH2(E2)
Host Gene: hsa-miR-363-3p, hsa-miR-217-5p, hsa-miR-576-5p, hsa-miR-708-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: RWPE-1, LNCaP, PC-3, DU145
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-363-3p, hsa-miR-217-5p, hsa-miR-576-5p, hsa-miR-708-5p
Biological function: promoted EZH2 expression, PCa cell growth, migration, and invasion
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

These findings show a novel autoenhancing EZH2_circEZH2-miR363/miR708_EZH2 regulatory loop, by which circEZH2 plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management.
Other information
Title:

circEZH2(E2) (/E3) is a dual suppressor of miR363/miR708 to promote EZH2 expression and prostate cancer progression.

Journal: Cancer Sci
Published: 2022/12/16
PubMed ID: 36519785